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Stem Cells to Re-attach Teeth

By: Ian Murnaghan BSc (hons), MSc - Updated: 9 Dec 2017 | comments*Discuss
 
Stem Cells Re-attach Teeth Tooth Grow

Tooth loss affects people in Britain and elsewhere around the world. While modern dentistry offers a number of options for missing teeth, these still take time and can be costly.

Helping Treat Tooth Loss

A new experiment, however, suggests we may one day be able to re-attach teeth by using stem cells. People can lose their teeth in many ways but gum disease is a significant problem for many people.

There are estimates that as many as eighty percent of adults suffer from some degree of gum disease. This infection is a very serious one that can ultimately lead to tooth loss later on in life. Other people may suffer trauma and lose their teeth.

A New Way to Battle Tooth Loss

In this recent study, researchers took stem cells from a specific ligament in the molars of mice. They treated these stem cells in the laboratory and then used them on barren molars. Once these molars were inserted back into the empty sockets of the mice, they eventually anchored back into the space.

Healthy Tooth Attachment Using Stem Cells

It was at around two months that stem cells began to create new attachments from the tooth to the bone. The result was that the attachment was a solid one and the re-attachment was considered a success.

As researchers looked at the tissue, they could see that surrounding the tooth were fresh ligament fibers and a substance called cementum, which is another part of a normal tooth connection. When compared to tooth molars that were re-attached without these stem cells, the attachment was unsuccessful.

Growing Teeth Using Stem Cells

Previous studies have looked at ways to grow teeth using stem cells. In another study, researchers used special tooth-shaped scaffolds along with specific proteins and growth factors to draw in stem cells and develop the bone. Perhaps most incredible was the fact that this growth occurred in only nine weeks. It’s a new direction of stem cell studies that can offer another potential option for people who lose their teeth.

Even more unique is that it works by attracting stem cells already in the person’s body rather than requiring an injection of stem cells from a donor. The quick recovery time and natural use of the body’s own resources would make this a particularly attractive dental treatment one day.

A Novel Treatment for Tooth Loss

For the study that looked at re-attaching teeth using stem cells, it is the first time that such a treatment has successfully been performed. It is thought that it would be valuable for those people who have experienced trauma and lost a tooth. This might be an athlete or someone who is in a car accident. In particular, it may be used for the significant numbers of people who suffer from severe gum disease and experience tooth loss.

Dental Implants Continue as a Treatment of Choice

Until then, there are still dental implants and these are largely successful. But a new stem cell treatment that utilises the body’s own resources to quickly re-attach teeth would be a welcome addition to dental options for missing teeth.

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Oct, 23, 2017 I had my partial tooth removed at Plainfield Oral & Maxillofacial Surgery, Plainfield, Indiana, I had bad experiences at that place, they were not treated me like a patient. As soon as when I walk into that place for my surgery appointment, they were ready to remove all my tooth. When I look at my X ray I had doubt in my mind, how many tooth I can be save, so I ask the dentist " how many tooth I can be save"? They told me, I have a bad teeths, the dentist give me ten anesthetics shots couple of minutes later I felt shortness of breath, I felt shaky, and I felt sleep apnea afterward. The dentists were telling me it was normal, Dr Raymond Lee come in the room, I explained to him, I felt shortness of breath, shaky, and I felt sleep apnea. He told me it was normal your body react to it. They were treated me so bad, pressing me down with instruments, pushing against my mouth. I remind doctor not to push against my mouth and my tooths. He keep telling me, he has to pressing down hard. I was bleeding so bad in my mouth, the blood went inside my throat. I had to ask for spray water and the suction so the blood were not in my throat. The blood went inside my throat, I was choking with blood and I throw up blood from my mouth. Dr. Raymond Lee told me "you can swallow your blood it not going to hurt you". He kept instruments pressure down against my mouth and the suction tube was pushing my throat. I had to pull the instrument away from me. Dr. Lee got upset he said, "hey! hey!" with his angry voice at me. He told me "you are not going to come back here again". The dentist was using dirty gauge pade already had blood stain wipe on my face. The lady at reception desk keep asking me, if I text my brother as he on the way! She told me, she can't hold of my brother. She said "you been here for four hours already". I felt sleep apnea, I just got my tooth surgery done, I had soaking wet dripping blood gauge pade inside my mouth. My brother had to come pick me up and take mehome. I wish I had keep my natural tooth deep cleaning instead of removed all my tooth, if I had my second opinion again. I know each one of us, we don't have to experience negative feeling without our natural tooth, we were not able to chew eat foods without our natural tooth. The orthodontics dentists all they are train to remove tooth they were not give good opinion, they only care about their business. I asking those of who still have your tooth take care of your teeths while you can, there is nothinglike your natural teeths. I share my experience to everyone so they will read my story, those of you who same experience like I had let you know you are not alone, I had go through same experience like we all have wish never have to remove tooth.
Basil - 24-Nov-17 @ 9:44 AM
Oct, 23, 2017 I had my partial tooth removed at Plainfield Oral & Maxillofacial Surgery, Plainfield, Indiana, I had bad experiences at that place, they were not treated me like a patient. As soon as when I walk into that place for my surgery appointment, they were ready to remove all my tooth. When I look at my X ray I had doubt in my mind, how many tooth I can be save, so I ask the dentist " how many tooth I can be save"? They told me, I have a bad teeths, the dentist give me ten anesthetics shots couple of minutes later I felt shortness of breath, I felt shaky, and I felt sleep apnea afterward. The dentists were telling me it was normal, Dr Raymond Lee come in the room, I explained to him, I felt shortness of breath, shaky, and I felt sleep apnea. He told me it was normal your body react to it. They were treated me so bad, pressing me down with instruments, pushing against my mouth. I remind doctor not to push against my mouth and my tooths. He keep telling me, he has to pressing down hard. I was bleeding so bad in my mouth, the blood went inside my throat. I had to ask for spray water and the suction so the blood were not in my throat. The blood went inside my throat, I was choking with blood and I throw up blood from my mouth. Dr. Raymond Lee told me "you can swallow your blood it not going to hurt you". He kept instruments pressure down against my mouth and the suction tube was pushing my throat. I had to pull the instrument away from me. Dr. Lee got upset he said, "hey! hey!" with his angry voice at me. He told me "you are not going to come back here again". The dentist was using dirty gauge pade already had blood stain wipe on my face. The lady at reception desk keep asking me, if I text my brother as he on the way! She told me, she can't hold of my brother. She said "you been here for four hours already". I felt sleep apnea, I just got my tooth surgery done, I had soaking wet dripping blood gauge pade inside my mouth. My brother had to come pick me up and take mehome. I wish I had keep my natural tooth deep cleaning instead of removed all my tooth, if I had my second opinion again. I know each one of us, we don't have to experience negative feeling without our natural tooth, we were not able to chew eat foods without our natural tooth. The orthodontics dentists all they are train to remove tooth they were not give good opinion, they only care about their business. I asking those of who still have your tooth take care of your teeths while you can, there is nothinglike your natural teeths. I share my experience to everyone so they will read my story, those of you who same experience like I had let you know you are not alone, I had go through same experience like we all have wish never have to remove tooth.
Basil - 24-Nov-17 @ 9:44 AM
Oct, 23, 2017 I had my partial tooth removed at Plainfield Oral & Maxillofacial Surgery, Plainfield, Indiana, I had bad experiences at that place and, they were not treated me like a patient. As soon when I walk into that place for my appointment, they were ready to remove all my tooth. When I look at my X ray I had doubt in my mind, how many tooth I can save, so I ask the dentist" how many tooth I can same"? They told me, I have a bad teeths, the dentist give me ten anesthetics couple of minutes later I felt shortness of breath, I felt shaky, and I felt sleep apnea afterward. The dentists were telling me, it was normal. Dr. Raymond Lee come in, I explain to him I felt shortness of breath, I felt shaky, and I felt sleep apnea. He told me "it was normal your body react to it". They treated me so bad, pressing me down with instruments, pushing against my mouth and my tooth. He keep telling me, he has to pressing down hard. I was bleeding so bad in my mouth, the blood went inside my throat, I throw up blood from my mouth. Dr. Lee told me "you can swallow your blood, it not going to hurt you". I felt pain throughout surgery, but I stay quiet during surgery. Dr. Lee instruments press down against my mouth and the suction tube was pushing my throat so, I had to pull away from me and Dr Lee got upset he said, "hey! hey! with his angry voice, you are not going to come back here again!". The dentist was using dirty gauge pade already has stain with blood on it. The from reception desk keep asking me if I text my brother as he on the way. She told me, she can not hold of my brother. She told me, "you been here for four hours already". My brother has to come pick me up and drove me to my house. They did not even complete my surgery, I went to different surgery place week ago to remove upper left tooth remove. It was the orthodontics specialist who refer me to Plainfield Oral & Maxillofacial Surgery. I wish never had to remove all my tooth, I can't chew or eat foods when I had my natural tooth. I did look like I use to all my tooth remove, I feel uncomfortable my gum are not look it use to close fit. I wish I had deep cleaning instead of removed all my tooth, if I had my second opinion again. I know each one of us, we don't have to experience negative feeling without tooth we were not able to chew eat foods like our natural tooth. The orthodontics dentists all they are train to remove tooth they were not give good opinion, they only care about their business. I asking those of who had tooth take care of you teeths while you can, there is nothinglike your natural teeths. I share my experience to everyone so they will read my story, those of you who same experience like I had let you know you are alone, I had go through same experience like we all had wish neve had to remove tooth.
Basil - 24-Nov-17 @ 6:16 AM
I would to be part of your trials, as I had a really bad experience with a dentist I had small hole in middle of my front tooth and rest of my upper teeth was perfect he instead of sorting it pulled 5 of my teeth I didn't know this at time as I was asleep he ruined my mouth, also scared me of going to dentist and my teeth are very bad and hate not being able to smile, and people looking at me.please
Mags - 13-Nov-17 @ 10:43 AM
Hi would love to be part of any trails. As I have mild gum disease and would love to have a healthymouth again.
Danp - 11-Nov-17 @ 9:21 PM
Hi My name is Stephenie and I had my four front teeth knocked out by a boy in School when I was fourteen, I am in my 50s now. I had a Stroke over a year ago and was unable to speak or walk..I can do both now..I also had PVNS in my knee and had the tumours removed with all clear results..it would be fantastic to have my own teeth again and I would help anyone get to have this on the NHS . When you need someone then please contact me. Thank you Stephenie
Steph - 9-Nov-17 @ 2:09 AM
I had a partial denture since I have been in 7th grade. Since the last 28 years I have a total of 11 teeth pulled. I have a crown on one but it still bothers me. My dentist is talking me into implants but would just love to have my really teeth back. I'm very interested to hear back on how this is going and when its able to be done on the public.Thank you
Trish - 5-Nov-17 @ 10:49 PM
I am a 65 yrs young man in great physical health.I have a great problem however in coping personally and socially with having 4 of my top teeth missing.The dentures I have been issued by the dentist continually work loose and haven't had a set that didn't hurt me or embarrassed me in company. If you are anticipating the need for any case studies in this field of dentistry, I would be absolutely delighted if you would consider me.I'm only an hour away in Fife.Thank you. Stephen.
Stevie - 1-Nov-17 @ 10:50 PM
I lost a few teeth due to gum disease so probably can't help me but there's so many that can benefit from stem cell teeth. I have a friend that went through a horrible experience during a root canal they broke her tooth now has implant that hurts terribly. Please help.
Sully22 - 23-Oct-17 @ 12:57 AM
I have a few cavities, and three chipped teeth, with no money or dental insurance to fix these woes. I would love to be a part of the human trials for this. I have anxiety, and depression and I feel confidentthat I would be a perfect candidate for this. I am 26 years old, and have had bad teeth for six years. I had braces when I was younger, and always practiced dental hygiene. However my teeth have suffered, and have not been dependable. I would love more than I can express to be a part of these trials. Not just for the potential benefit to myself. But also because for so many like me it could make a huge difference. And for the dental industry it could make a huge difference. I am willing to try pretty much any thing to not have to resort to implants, and the crippling depth I would be Ithereafter. Sincerely Katie.
Katie - 17-Oct-17 @ 8:22 PM
If you want a human trial please consider me. Contact me with email.
Sunu - 16-Oct-17 @ 1:59 PM
I would love to be considered if looking for someone for stem cell trial, I dont like to smile or show my teeth due to bad experience by dentist her in uk ,had a gap in middle of front teeth and thought would fill it only he pulled just about all my healthy teeth left me with four back teeth in my top it has scared me of dentist and my teeth are needing sorted only I dont want to loose anymore so I suffer realy bad pain and makes me sick to my stomach headaches, plus not good role model for my son who was born with learning difficulties and who I have been on my own with since he was born, when he pulled my teeth he put in a dental plate I have had to suffer through negligence.I have no confidence in myself.thanks
Mags - 31-Aug-17 @ 4:39 PM
Hi.. Am in India. Plz suggest where and how can I get my tooth regrown using Stem cell.
Krish - 21-Aug-17 @ 7:15 PM
I have a condition known as GAP vasculitisI have recently lost my front toothbecause of my illness and medication I am unsuitable for an implant.I would be a very willing volunteer to see if a new tooth could be grown. I am hoping this procedure will be available very very soon.
Nicky - 9-Aug-17 @ 8:03 PM
I have a tmj and due to a wrong dental proceedure have lost2 Molars and one tooth is reduced with a crown which keeps hurting all the time. And this has happened on the same side where my tmj is very damaged and unstable. This is causing me a lot of facial pain and instability of my joint. Hope this treatment starts on humans really fast. When can we hope for this to begin on human beings. It will be a blessing for millions of sufferers as tooth loss and tooth pain both are scary. i am curious to know that the stem cells will be taken from the patients mouth itself or are they external stem cells. If from the patient itself will it be taken from a tooth or the gums?Kindly contact me with details.
Tina - 9-Aug-17 @ 1:39 PM
I would love to have the opportunity to try this. I'm missing 8 teeth and another 3 are now wobbly. This is a life changing experience
Danip - 6-Aug-17 @ 9:52 PM
I was doing research on Dental implants I came across stem cells I have never heard of it but there has been times when I have thought why can't all natural teeth grow back desperately in need of trying this if you need someone to test it on feel free to call me I would love to be there to try this out for you thanks for the hard work you all has put into the research keep up the good work and hope to hear from you soon if you need me feel free to call me
San - 23-Jun-17 @ 3:20 PM
I want the whole lot replaced as they are poisoning my blood 12 are missing I getting Chinese Cupping Blood Letting for 14 weeks now and black blood comes from top of head but red across the back shoulders back spine and hips buttocks The amalgam is the root cause of all my problems at 67 caused all my ringing ears 90% bad I blame the blood poisoning in my head frequencies nerves etc stuffs the whole body balance up since 8 years old ringing ears dentistry and toxins I like to have this treatment
Moai - 27-May-17 @ 11:22 PM
The first dental practice that offers to grow new stem cell teeth (using the scaffolding technique) for ordinary patients, will make world headlines... It will be inundated with requests for new patients. I wonder if it will ever happen.
Ella - 21-Feb-17 @ 9:06 PM
Hello I too would love to be considered for stem cell regeneration of teeth. If you should ever need someone for these trials please consider me and contact me via email. Thank you.
salem930 - 14-Jan-17 @ 1:43 AM
My son is 7, and he just lost one of his incisors.The dentist says that once he is a bit older, they can put a bridge on; however,that would destroy two more of his teeth. Originally,he went to a pediatric dentist which was supposed to be placing a cap over his tooth while he was put to sleep. After the procedure,I was approached and informed that they had to remove his baby tooth and an x-ray showed what they called a "phantom tooth."They searched for this phantom tooth and it was nowhere to be found. When his adult tooth came in, it wasn't rooted properly and appeared to only be halfway in and the other dentist applied something to make his tooth appear more normal.Now it has come out completely,and there really aren't any good options for his treatment. Are there any current trials for children?
ACB - 24-Dec-16 @ 1:28 AM
Hi Sir Iam lakshmi is this procedure i.e. teeth regrowth using tooth shaped scaffolds has been done on human beings till now and when this will come to India and how much it costs.
laxmi - 23-Nov-16 @ 10:42 AM
When this new procedure will be available in India
laxmi - 23-Nov-16 @ 10:37 AM
@Midi - yes, I had all my teeth filled too when I was a kid - dentists used to find holes where there were no holes just so they could claim the money for a filling from the NHS. My mother was scrupulous about me cleaning my teeth, and yet, every time I went I had to have one. She thought she was doing the right thing, when it turns out that in reality she wasn't. Now I have a mouth full of leaky amalgam and my teeth are ruined.
JoJo - 30-Sep-16 @ 11:05 AM
My childhood dentist filled my mouth with unnecessary fillings.As a child I had very few sweets my parents didn't buy them.And I cleaned my teeth every night yet my dentist filled my mouth with fillings.When I asked him about them he told me I had soft enamel. I knew it was a lie but I was a child, and was at that time taught not to question adults.Ten years later my fillings are decaying and my teeth are cracking up. My brother is in the same situation with the same dentist.I have been in agony on and off for years because of this.Just for the record my dad rarely visited the dentist and he had one filling his entire life and his teeth were in good condition right up till he died of cancer a couple years ago. There are hundreds of people like me with teeth problems due to bad unscrupulous or incompetent dentists.This treatment would help these people to be able to have pain free teeth.Even though I am poor I would save up and pay for this just to be pain free but be able to chew normally.So many people are so desperate for this treatment to become a reality.It is something that would change the lives of many thousands and I pray for it to hurry up.
Midi - 29-Sep-16 @ 12:14 PM
fliss - Your Question:
I'm also surprised and frustrated that human trials are not being done yet for growing your own teeth through stem cells. I have an inherited disease, where all my teeth started to go bad at the age of 5, and by the time I was in my early 20's, I had a full top denture. It was hell having to wear the thing being so young.I've known for years that this is possible, so where are the trials? I would have thought that America would have already done them. So many other trials using stem cells have been done for other things. You can even grow nerves back, retinas, hearts, livers, kidneys, etc; etc; so if I could grow my own teeth it would be wonderful! How would we all know though if any trials were to start? I know there are risks to any trials, but I would certainly be willing to take part.

Our Response:
I can direct you to the EuroStemCell site here which should give you more information. I hope this helps.
ExploreStemCells - 31-Aug-16 @ 11:35 AM
I'm also surprised and frustrated that human trials are not being done yet for growing your own teeth through stem cells. I have an inherited disease, where all my teeth started to go bad at the age of 5, and by the time I was in my early 20's, I had a full top denture. It was hell having to wear the thing being so young. I've known for years that this is possible, so where are the trials? I would have thought that America would have already done them. So many other trials using stem cells have been done for other things. You can even grow nerves back, retinas, hearts, livers, kidneys,etc; etc; so if I could grow my own teeth it would be wonderful! How would we all know though if any trials were to start? I know there are risks to any trials, but I would certainly be willing to take part.
fliss - 30-Aug-16 @ 2:49 PM
Please start this product soon
abhi - 30-Aug-16 @ 12:00 AM
After doing a liquid diet for several months in my late 30s my gums receded badly; now in my mid 50s following further diets, despite taking extra vitamins/medication my gums have receded further and most of my teeth are slightly loose so I am being referred to hospital - I am very interested in finding any stem cell trials for reg rowing gums as my problems are with my gums not my teeth.Are there any clinical trials or stem cell treatments out there, and how can one sign up or be referred to it?
Raindrops - 27-Aug-16 @ 12:13 PM
Hi, I'd really like to be able to take part in the trials for teeth regrowth if that's at all possible as I've had to have quite a lot of my teeth removed due to a few accidents in the past, some caused by my older brother while he was drunk (he's kinda violent!) and I'm currently having to wear a denture which I hate as it's hard to eat with, makes me feel horrible / lack of confidence and so on... I live in Scotland.. If I can help out anyway what so ever be it in trials or so on, then I'd be more than willing to test the stem cells out, esp if it'll help me to regrow my teeth, regardless of the pain that might be involved or not as it'll be worth it in my opinion... Thanks a lot ..
VP - 23-Aug-16 @ 1:23 AM
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