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Stem Cells to Re-attach Teeth

By: Ian Murnaghan BSc (hons), MSc - Updated: 16 Mar 2018 | comments*Discuss
Stem Cells Re-attach Teeth Tooth Grow

Tooth loss affects people in Britain and elsewhere around the world. While modern dentistry offers a number of options for missing teeth, these still take time and can be costly.

Helping Treat Tooth Loss

A new experiment, however, suggests we may one day be able to re-attach teeth by using stem cells. People can lose their teeth in many ways but gum disease is a significant problem for many people.

There are estimates that as many as eighty percent of adults suffer from some degree of gum disease. This infection is a very serious one that can ultimately lead to tooth loss later on in life. Other people may suffer trauma and lose their teeth.

A New Way to Battle Tooth Loss

In this recent study, researchers took stem cells from a specific ligament in the molars of mice. They treated these stem cells in the laboratory and then used them on barren molars. Once these molars were inserted back into the empty sockets of the mice, they eventually anchored back into the space.

Healthy Tooth Attachment Using Stem Cells

It was at around two months that stem cells began to create new attachments from the tooth to the bone. The result was that the attachment was a solid one and the re-attachment was considered a success.

As researchers looked at the tissue, they could see that surrounding the tooth were fresh ligament fibers and a substance called cementum, which is another part of a normal tooth connection. When compared to tooth molars that were re-attached without these stem cells, the attachment was unsuccessful.

Growing Teeth Using Stem Cells

Previous studies have looked at ways to grow teeth using stem cells. In another study, researchers used special tooth-shaped scaffolds along with specific proteins and growth factors to draw in stem cells and develop the bone. Perhaps most incredible was the fact that this growth occurred in only nine weeks. It’s a new direction of stem cell studies that can offer another potential option for people who lose their teeth.

Even more unique is that it works by attracting stem cells already in the person’s body rather than requiring an injection of stem cells from a donor. The quick recovery time and natural use of the body’s own resources would make this a particularly attractive dental treatment one day.

A Novel Treatment for Tooth Loss

For the study that looked at re-attaching teeth using stem cells, it is the first time that such a treatment has successfully been performed. It is thought that it would be valuable for those people who have experienced trauma and lost a tooth. This might be an athlete or someone who is in a car accident. In particular, it may be used for the significant numbers of people who suffer from severe gum disease and experience tooth loss.

Dental Implants Continue as a Treatment of Choice

Until then, there are still dental implants and these are largely successful. But a new stem cell treatment that utilises the body’s own resources to quickly re-attach teeth would be a welcome addition to dental options for missing teeth.

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[Add a Comment]
Hi i have been suffering from gum disease for a few years now and have had several teeth extracted as well as teeth being weak and all gradually breaking. Going to the dentist is far beyond my reach as they are wickedly expensive. I live in Australia and we do have public dental but the waiting list is so long that i will be toothless by the time o get anywhere near a consultation. Quite disgusting really in a supposed wealthy country such as this. I would like to be advised though, if and when there will be possible trials available in Australia for the stem cell replacement. I have searched and searched and am unable to find anything. I would gladly put my hand up as a guinea pig for this procedure as each day is becoming more and more embarressing as each tooth is lost. Please help.
Cherbear - 16-Mar-18 @ 9:20 AM
Hi there, the research you’ve shared shows great promise. I would love to keep updated and understand how soon would something like this be available in the real world. If at all you’re looking to find participants for the human trials, I would like to throw my name in the ring. I am 28, healthy and with an average set of functional teeth (a few fillings over the years). However, I do have a root canal treated broken tooth that has deteriorated and can no longer contain a filling or be covered with a crown. My jaw bone and gum line are in excellent condition though. Whether you can regrow the existing tooth or generate a new one, am game! If you’re looking for a participant like that, well then, we are made for each other, clinically speaking! :) Thanks for the fascinating read. I hope it becomes a reality in the next few years (and not decades lol).
Sherry - 8-Mar-18 @ 11:40 PM
I have experienced gum disease for some time. I absolutely hate my teeth due to receding gums. There have been times where I have been in a dark place. AlthoughI am a senior citizen, there have been times that I have considered suicide. Harsh, but depressed. Thank you. I would love to be part of any trial.
N/a - 28-Feb-18 @ 7:26 PM
Hi I have many fillings that I would love to get rid of . Also I have a 5 year old who had suffered with bad teeth
Teeth - 24-Feb-18 @ 1:57 PM
Hello, after reading this and other articles I would very much like to be part of any trials if it would be the right course of action for my problem. I have gum disease which has resulted in bone deterioration of my upper jaw, especially the socket which houses my left front tooth, also this tooth is suffering bone deterioration which has resulted in an ever widening gap with a rapidly receding gum. This has made me so self conscious as I won't smile or laugh without covering my mouth and CERTAINLY won't have pictures taken, otherwise my oral hygiene is great with very few fillings (maybe 2). Hopefully restoring bone loss may make me a viable candidate. Thanks for reading.
Sara - 23-Feb-18 @ 10:28 PM
Hi im a father of 7 kids and a beautiful cna nurse . I know this is 1 in a million but im 36 and loosing my teeth i would like to try this out . it would be a blessing to have my teeth back.
Juni - 23-Feb-18 @ 1:28 AM
I would love to be in the clinical study. I don't have any top teeth and have my bottom are gone and the Dentures rub blisters on my gums even if it is right. Thank you very much for reading this
Rissa - 20-Feb-18 @ 11:44 PM
Am facing losing all my teeth due to infection but have No cavities at all just cant imagine having no teeth please help in Arkansas
Rita - 18-Feb-18 @ 9:12 PM
Please!! I would love to be part of this clinical trial.I list all wisdom teeth at 18 as my parents didn't believe in doctors or dentists.Now at 53, I have many fillings and crowns, and a few months ago i had a tooth pulled.My oral surgeon is trying to rebuild the bone with a graft, but one side fell out.Now months later. I still have pain while eating or drinking cold things.
Crystal - 17-Feb-18 @ 7:38 AM
this Research for me wouldn't be life changing it would be life-savingnot being able to smile I was thinking a lot from me it has nothing to do with self-esteem but embarrassment I'm ashamed the type of shame that has led me down a path to a dangerous deep depression that I cannot seem to escape from my personality is that of a Smiler and an individual who loves to laugh but the shame I have has taken the most important part of me away it's affecting my overall health and hygiene I would do almost anything to be a test subject for This research and if it turns out successful I would oweHarvard with my life
T bone - 16-Feb-18 @ 6:37 AM
Hi! it would completely change my life...
dreemweever - 16-Feb-18 @ 12:06 AM
Hi. I would like to be part of this traial. I have missed all the bottom back teeth and really want to regrow my teeth.
Manis - 13-Feb-18 @ 8:01 PM
My 12 year old child, has 2 baby teeth still in & we decided to leave them, so they can keep the teeth properly spaced, but are now starting to be self absorbed by her body & will need to be removed, but her adult teeth that are supposed to be growing behind them, are missing, with no signs of growing anywhere. We don't like the painful options of using the beneslider & mesioslider to remedy this gap. She also doesn't want to have screws & fake teeth. And It dawned on me that there must be a way to regrow teeth, so now I'm on a hunt for someone to do that.
Explorestemcell.Co. - 13-Feb-18 @ 4:03 AM
On my 40´s i have lost 10 pieces of my mouth, starting for a bad habit,and ignorance of my parents, first 5 i vee lost it before i got 15 years old and an unfortunated accident when i was 17 since then i have lost my front theet and my life has been chged little by little from bad to worst.already try to kill myself because of this problem, i feel so bad, can´t eat proper,cant get close of a woman, my self estime is totally down,i do really want to recover my smile and enjoy life again. Please consider myself to be the first patients to try on, im so interested, i have follow this line for years already, this is a last chance for someone like me. i can give my life for something like this thanks
help - 12-Feb-18 @ 1:59 AM
I would live to be part of this trial.
Jamie - 7-Feb-18 @ 5:38 PM
I got gum disease in the Gulf War, and have been battling to keep what teeth I have left. I would love to participate in the trials. Thank you.
Naitto - 7-Feb-18 @ 3:20 PM
If I could get this opportunity to be a part of this it would be wonderful!!!! I am a survivor of domestic violence... Lost all of my top teeth... I tried a denture and it hurt way to much to wear it.... I want to do implants but don't have 30,000 sitting in the bank... I want to be able to smile again and feel confident about myself again!! If you do need someone for a trail, I would love to be able to do it!!
Missy - 3-Feb-18 @ 11:28 PM
My son is three and has severely damaged upper front teeth from medication at birth.There is literally nothing left.I would like to know if this stem cell technology is available to children with baby teeth still?
klops - 2-Feb-18 @ 6:16 AM
I have a problem with my tooth at a very young age, i always have cavity ang now i have dental filling but they are now starting chipping and now i have a huge hole in my tooth, so i would be so happy if i could be part of stem cell trial. That would be a blessing and i will be grateful for the rest of my life
Stephanie - 28-Jan-18 @ 4:22 PM
@Vanessa - you need to see a dentist. I'd ask your doctor if it's OK. I'm sure it will be. You can't continue to put up with constant tooth ache :(
NN - 22-Jan-18 @ 12:52 PM
Hi all, I had cancer at the age of 14. I was never told that I should have treatment on my teeth when I was on the treatment for cancer. Now I have only 7 teeth left. I can never eat and not feel paid.I try to look at the bright side of my life and yes I am greatful to be alive but I just can't life with the paineveryday. Please If someone can please help me I would be forever greatful. I now live life not being able to smile like a normal person. Having this treatment will be life changing for me. I am scared to move the 7 teeth that I have left cos it will just be come hard to eat and talk. I'm in pain all the time cos the 7 teeth that I have are dying. I live on pain killers at the moment. Please help me
Vanessa - 21-Jan-18 @ 10:06 PM
Just had all my teeth pulled out last week and looking at getting implants in the next 4 months. So reading this information is all new to me and a very good option. When will this be available and what cost. cheers
Wyer - 21-Jan-18 @ 6:53 AM
My man on my face book Had all front teeth accident at 12 False teeth drove him crazy n false aquized sex offense made him now in jail. N may have Mosaic down syndrome So metal n him are no way ho say He needs help Great nat ego opportunity I proved the case to be cleared by CIA So his a Lil movie star N my 6 ocean born His a good soul Positive past lives Waterman. Great opportunity For advertisement.
Flowerlady - 16-Jan-18 @ 7:55 PM
I am in need of services now.Cannot bare the thought of dentures and no teeth.I know the material dentists use will be hard and hurt my gums.Most of us could never afford implants, the cost is like buying a new car.Handsdown, this would be the best option and a great blessing!!!
Cyn - 15-Jan-18 @ 5:08 AM
I have no molars only front teeth. I would love to participate in your experimental procedure...be your lab rat so to speak... I'm in line to be the next James bond...but the moment I'm 00teeth not 007...can send you x-rays. Please help I am ready to jump on a plane at anytime..to anywhere.
007 - 12-Jan-18 @ 1:30 AM
I would love the opportunity to be in these trials.. I was in a car accident that killed my front teeth.. and I also had my wisdom teeth come in and smash to pieces alot more.. I would love the chance to be able to eat things I can't and smile again!
Jecie - 7-Jan-18 @ 3:03 AM
I have had problems with my teeth from a young age, I would love to be part of your trails...??
Janet - 6-Jan-18 @ 11:40 PM
I too am very interested in this research as Ihave lost a few teeth to peridontal disease. I have one implant and I would love to have a few more but it is far to expensive. I would be very interested in stem cell teeth regeneration I believe there is still much research to be done but I would be very grateful to be kept informed.
Robbie - 31-Dec-17 @ 7:59 AM
I always use to be a victim of domestic violence.I will love if I can get the opportunity to be part of stem cells trial.I will be so grateful for the rest of my life.Please considered me.Very truly yours,Eloisa Batista
Elo - 30-Dec-17 @ 2:55 PM
I was born with a skin dis-ease, Dystrophic Epidermolysis Bullosa. Any slight trauma to the skin, mucousa membranes causes blistering &/or open wounds that heal like burns (a consistent cycle). For my 45 years, I have experienced the good and bad in dentists. I was referred to "Hospital Dentistry", under anesthesia, in 2002 to remove my two fronts, and to resolve other issues at the time. I've had a stay plate since then. But now in 2017, I have severe tooth loss, some broken nuns, etc. Teeth 1 thru 9 are gone, 4 is a broken nub. 14, 15, 19, 21, 23-28 are in place. The others gone. With 20 and 22 as root canal damaged nubs. Without surrounding teeth, the stay plate no longer stay in place I was told in June of 2017, that I would have to have all remaining teeth removed. I am not satisfied with this recommendation. My family and congregant members are on alert for such a resolution for me. All of my life I have been use to extreme pain with demtist, but have dealt with it like a champ to survive. My strength comes from my spiritual foundation. I am a divorced mother of 2 sons, with which my first born of the 2 was murdered in 2015, at 21 years of age. Despite the tragedy, my now 22 year old son, has gone on to become a Special Education Paraprofessional, in addition to being a college student, singer/songwriter and consistent member of the congregation that I've been singing in, my whole life. I am glad that my son uses the beautiful gift of song thay has been passed down to him through my own. It is very difficult for me to use this gift with my mouth looking like the great Moms Mably on stage, Rest Her Soul. I have been greiving the loss of my son and after this is when several of those lost teeth have crumbled. I would appreciate information ASAP, on how to be part of this much needed technology, in order to maintain quality of life, for the rest of my years on this earth.Thank You in advance for your reply. Shalom.
AJ - 25-Dec-17 @ 2:23 AM
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