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A Rare Side Effects of Stem Cell Therapy: A Case Study

By: Ian Murnaghan BSc (hons), MSc - Updated: 11 Nov 2018 | comments*Discuss
 
Stem Cells Rare Side-effects Tumour

There is no doubt that stem cell therapy holds enormous potential. Unfortunately, this potential also brings with it side-effects, some particularly severe. Such was the case during a therapy that used human foetal stem cells.

The boy in the case suffered from a rare genetic disease known as Ataxia Telangiectasia. This disorder affects many areas of the body and can cause significant disability. The body does not coordinate properly and those who suffer from the disease have a weak immune system as well as problems with their respiratory system.

Unexpected Consequences of Stem Cell Therapy

After undergoing foetal stem cell therapy at a clinic, the boy developed abnormal growths in his brain and spinal cord. The growths were found approximately four years after he had received the stem cell therapy.

While there have been some cases reported where experimentation on rodents resulted in the growth of tumours after stem cell injection, this hadn't been documented in humans after foetal stem cell therapy. Researchers also knew that this risk in rodents could be reduced if the stem cells were differentiated before they were injected. This means that the stem cells were coaxed into the desired body cell for the therapy prior to injection.

Examining a Benign Tumour

But how did the researchers know that in this boy's case, the tumour was indeed from the stem cell therapy? It was all understood after the spinal cord growth was operated on and removed from the boy. Doctors found that it looked like a glioneuronal tumour, which is a benign kind of neural tumour. After more examination, it was determined that this tumour couldn't have stemmed from the boy's own tissues.

A Weakened Immune System

As they tried to understand what went wrong, they considered that the very weak immune system that is commonly seen in Ataxia Telangiectasia could have contributed to the growth. In a sense, the boy's body was an ideal vessel to nourish the growth of this kind of tumour.

In a person who has a healthy immune system, the normal 'checks' on the body would be more likely to prevent a tumour from establishing itself. We have known for some time now that there is the potential for stem cells to trigger the growths of tumours but the reality has been that this is a rarity.

What it Means for Stem Cell Research

Although this rare side-effect of stem cell therapy may be used as part of a case against stem cell research, this would not be a fair approach. Even the authors of the report state that their findings do not imply that we should stop stem cell research.

Rather than put a stop to stem cell research, it has been suggested that we need to spend more time looking at the Safety of Stem Cells. We should try to find out more about what can potentially go wrong and then develop safeguards to reduce any risks associated with stem cell therapies. This way, we can get the most benefits from stem cells while minimising any chances of side-effects along the way.

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K - 24-Oct-18 @ 6:24 PM
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Grace - 12-Oct-18 @ 1:25 PM
Is it normal to miss a menstrual period after stemcell stc30 because I'm a whole month late and have taken numerous pregnancy test and all negative
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Chiso - 20-Sep-18 @ 6:23 AM
Try Purtier Placenta. It is an oral type of stem cell or live cell therapy that helps people who suffer from heart problems, cancer, diabetes, parkinsons, autism and more. Search for the product and watch you tube videos showing testimonials on how this product helped them.
aileen - 13-Sep-18 @ 8:26 AM
My doctor recommends Stem cell therapy for me all thou I am basically a healthy Man of 79 yrs ol. The reason he gives is Stem cell therapy will keep me healthy for a longer period of time. I am not sure of what to think.Naturally I want to live healthy as long as possible.What would you do.? TY
Daniel Nociaro - 28-Aug-18 @ 4:07 AM
My daughter is suffering from secondary microcephaly, and it's one of the option I have for my daughter to have her brain grow to its normal size according to her age is to have a stemcell therapy. But the therapy is very costly in Switzerland, I'm just an employee of a private entity. My question is: 1. Is this really effective (stemcell therapy)for my daughter's condition? 2. What is the less cost stemcell therapy that I can possibly afford? Thank you
Rey - 25-Aug-18 @ 8:15 AM
I got a mesenchymal stem cell jaw graft 15 months ago to assist a dental implant on a severely abscessed tooth. I now know that my immune system was severely compromised most likely due to existing thyroiditis, that, at the time, was not diagnosed. I took 1200 mg of cipro before/after the procedure and had flu-like symptoms post-op which the periodontist chalked up to a reaction to the antibiotic. I was then switched to Flagyl. This was unusual because 9 years earlier, with the same practitioner, I had not had a reaction to the graft. Since then I have grown multiple hemangiomas in my spleen, liver cysts and have a R upper pole angiomyolipoma that is symptomatic, all found incidentally when I had kidney stones. I also grew a tophus, which has since gone away or remodeled. Studies for organs include labs, multiple US, CTs, MRI, Tc-99 study. My immune system is absolutely wonky, having anything from localized skin eruptions to food reactions which required steroids. GP puzzled, passed on to various specialists who don’t seem to put all the pieces together. Thyroiditis most likely confirmed with heterogeneous thyroid with hyperemia on US and enlarged lymph nodes. Labs pending this week. Live in US, would love to hear from authors regarding possibility of graft prompting ancillary mesenchymal growth in other organs. Genetic factors not ruled out.
Mary - 8-Jul-18 @ 11:30 PM
I got a mesenchymal stem cell jaw graft 15 months ago to assist a dental implant on a severely abscessed tooth. I now know that my immune system was severely compromised most likely due to existing thyroiditis, that, at the time, was not diagnosed. I took 1200 mg of cipro before/after the procedure and had flu-like symptoms post-op which the periodontist chalked up to a reaction to the antibiotic. I was then switched to Flagyl. This was unusual because 9 years earlier, with the same practitioner, I had not had a reaction to the graft. Since then I have grown multiple hemangiomas in my spleen, liver cysts and have a R upper pole angiomyolipoma that is symptomatic, all found incidentally when I had kidney stones. I also grew a tophus, which has since gone away or remodeled. Studies for organs include labs, multiple US, CTs, MRI, Tc-99 study. My immune system is absolutely wonky, having anything from localized skin eruptions to food reactions which required steroids. GP puzzled, passed on to various specialists who don’t seem to put all the pieces together. Thyroiditis most likely confirmed with heterogeneous thyroid with hyperemia on US and enlarged lymph nodes. Labs pending this week. Live in US, would love to hear from authors regarding possibility of graft prompting ancillary mesenchymal growth in other organs. Genetic factors not ruled out.
Mary - 8-Jul-18 @ 2:41 PM
I got a mesenchymal stem cell jaw graft 15 months ago to assist a dental implant on a severely abscessed tooth. I now know that my immune system was severely compromised most likely due to existing thyroiditis, that, at the time, was not diagnosed. I took 1200 mg of cipro before/after the procedure and had flu-like symptoms post-op which the periodontist chalked up to a reaction to the antibiotic. I was then switched to Flagyl. This was unusual because 9 years earlier, with the same practitioner, I had not had a reaction to the graft. Since then I have grown multiple hemangiomas in my spleen, liver cysts and have a R upper pole angiomyolipoma that is symptomatic, all found incidentally when I had kidney stones. I also grew a tophus, which has since gone away or remodeled. Studies for organs include labs, multiple US, CTs, MRI, Tc-99 study. My immune system is absolutely wonky, having anything from localized skin eruptions to food reactions which required steroids. GP puzzled, passed on to various specialists who don’t seem to put all the pieces together. Thyroiditis most likely confirmed with heterogeneous thyroid with hyperemia on US and enlarged lymph nodes. Labs pending this week. Live in US, would love to hear from authors regarding possibility of graft prompting ancillary mesenchymal growth in other organs. Genetic factors not ruled out.
Mary - 8-Jul-18 @ 6:23 AM
I have a dermoid ovarian cyst can stemcell help cure it. I don't want an op
kay - 7-Jul-18 @ 7:20 AM
Does Double stemcell treatment causevomiting
Jare - 30-Jun-18 @ 4:03 PM
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andy - 26-Jun-18 @ 5:08 AM
My son is 5years old with Autism. I wanted to try Stem Cells therepy but wanted to know the best way of doing it?? Is it by useing Adult Stem Cells or Embryotic Stell Cells?? How many times??
Lucky - 23-Jun-18 @ 6:40 AM
I have a sever brain injury, it's going on 21 years. I'm interested in getting stem cell therapy. But, I'm also hesitant about getting it, I run a business. What can it actually do for me, that I can't do for myself. Unless it can help me remember things, breath easier, and stop my focal seizures, then I don't see any point to it.
Julie - 26-May-18 @ 10:10 PM
is STC 30 a medically validated product
mickey - 16-May-18 @ 2:37 PM
My son is 5years old with Autism. I wanted to try Stem Cells therepy but wanted to know the best way of doing it?? Is it by useing Adult Stem Cells or Embryotic Stell Cells?? How many times?? Side effects after??
Lucky - 10-May-18 @ 7:04 AM
Please tell me the side effects of plant based stem cell drug called stc 30 if administered to an 8year old child who just had a brain tumor surgery. Thanks for your reply in advance.
mac - 25-Apr-18 @ 10:33 PM
There is this Malaysian plant based stemcell drug called stc30. How safe is it especially administered to a child patient just from a brain tumor surgery. Please reply as I have already bought the drug by yet to administer to him. He's 8years old
mac - 25-Apr-18 @ 10:29 PM
I'm suffering from agent urination and blood bleeding can I use this stand cell. Because many doctors failed treat me the hole Zimbabwe.
Diwaprinters - 5-Apr-18 @ 9:34 AM
having kidney problem can stemcell restore the kidney?
Engr - 23-Feb-18 @ 7:28 AM
My son is 2.5years with Autism. I wanted to try Stem Cells therepy but wanted to know the best way of doing it?? Is it by useing Adult Stem Cells or Embryotic Stell Cells?? How many times?? Side effects after??
Amjad - 31-Jan-18 @ 9:08 AM
I'm 42 year, i have complete hepatic portal vein thrombosis, my spleen is enlargedand part of my liver is cirrhosis for the last three years. can i use double stem cell? what could be the side effects?
aunt - 3-Nov-17 @ 11:35 AM
I am diabtic and suffering from cardiatic respira tory problem and also having spondylitis Already consumed one of double stemcel Box andshall I continue same and How can I get Medicine and to whom I may Contact adress and phone numbers l
Babu - 24-Oct-17 @ 4:21 PM
My sister swallowed my dad's stem cell pill and has not been feeling too well.Taking the pills without a doctor's prescription has any adverse effect??
Jules - 9-Sep-17 @ 8:29 AM
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