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Pluripotent Stem Cells

Author: Ian Murnaghan BSc (hons), MSc - Updated: 18 June 2014 | commentsComment
 
Stem Cells Foetal Tissue Humans Animals

The concept of stem cells can seem a complicated one and you may have seen foreign words such as 'pluripotent' written in magazines or discussed on television. Stem cells describe all of the cells that can give rise to the different cells found in tissues. There are however, different types of stem cells. One such type is a pluripotent stem cell.

What Are Pluripotent Stem Cells?

Pluripotent stem cells are often termed 'true' stem cells because they have the potential to differentiate into almost any cell in the body. This means that under the right circumstances, a stem cell that is isolated from an embryo can produce almost all of the cells in the body. Yet after this embryonic development stage is over, the stem cells no longer have this unlimited potential to develop into all cell types. Their pluripotency is thus lost and they can only become certain types of cells.

What Makes a Stem Cell Pluripotent?

To understand how a cell becomes pluripotent, it helps to consider the human body in the very early stages of development. After an egg is fertilised by a sperm, a single cell results. This cell - the fertilised egg that is totipotent - has the potential to create an entire organism. In the initial hours and days following fertilisation, this single totipotent cell divides into more totipotent cells that are exact copies of the original.

Approximately four days after fertilisation, the totipotent cells start to specialise and form a cluster of cells known as a blastocyst. The blastocyst has yet another smaller group of cells known as the inner cell mass and it is these inner pluripotent stem cells that will go on to create most of the cells and tissues in the human body. These pluripotent stem cells are therefore different than totipotent stem cells because they don't develop into a complete organism. As such, a pluripotent cell won't give rise to the placenta or other tissues that are vital for foetal development. It will still develop into the other specialised cell types in the human body, such as nerve or heart cells.

You may have also heard the term 'stem cell line.' Stem cells from embryos can be used to create these pluripotent stem cell 'lines,' which are grown in the laboratory or cultured from foetal tissue.

Types of Pluripotent Stem Cells

There are several key types of pluripotent stem cells:
  • Embryonic stem cells are isolated from the inner cell mass of the blastocyst. The embryos are excess ones produced from in vitro fertilisation, but the practice is still controversial because it does destroy the embryo, which could have been implanted to create a baby.
  • Embryonic germ cells are taken from aborted foetuses and these pluripotent cells are derived from very early cells. These early cells are those that can become sperm and eggs.
  • Embryonic carcinoma or cancer cells are isolated from a type of tumour that sometimes occurs in a foetus.

Benefits and Future of Pluripotent Stem Cells

Pluripotent stem cells provide a chance to obtain a renewable source of healthy cells and tissues to treat a wide array of diseases such as heart disease and diabetes. Burn victims and those who suffer from autoimmune diseases such as Parkinson's can all potentially benefit from the use of pluripotent stem cells.

Pluripotent stem cells have a vast potential for the treatment of disease, namely because they give rise to the majority of cell types in the human body. These include muscle, blood, heart and nerve cells. Another potential use for pluripotent stem cells involves the generation of cells and tissues for use in transplantation.

Pluripotent stem cells can evolve into specialised cells that ultimately can replace diseased cells and tissues. Drug research is another area that pluripotent stem cells may benefit. Animals are a commonly used model to assess the safety and use of drugs. Instead of initially testing drugs on animals, they can be evaluated through testing on cells grown from pluripotent stem cells. Those drugs that appear tolerated and safe can then progress to testing on animals and finally, humans.

Challenges for Pluripotent Stem Cells

Often, the discoveries with the greatest therapeutic benefits present the most difficult challenges; this is particularly true for pluripotent stem cells. Researchers are attempting to learn ways of controlling the development process of pluripotent stem cells into the many different cell types in the human body. Another current challenge is that the cells used in research are rejected from a person's body due to their immune system. More controversial is the fact that many scientists and members of the public have ethical issues with the use of pluripotent stem cells from human embryos or foetal tissues.

The positive uses of pluripotent stem cells are enormous but new research and ethical challenges must be taken into account before the public can reap the full benefits. For those who suffer from the many diseases that may be treated by pluripotent stem cells, additional knowledge and research will hopefully come sooner rather than later.

What to Read Next...

Find out more about stem cell and the chanelleges that face stem cell therapy by having a read through our article The Challenges of Stem Cell Therapy.

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your article is so hopeful for me.sir, my husband is a azoospermia patient. can my husband cure by stem cell therpay. if it is yes means, where can i go for this treatment. please help me sir.
sri85 - 18-Jun-14 @ 9:26 AM
Yes there are other ways to get stem cells.They have found ways to get cells from spinal tissue, bone marrow and even fat.They are finding that most if not all organs and tissues in the body do contain "some" stem cells.But it has several problems.First, the cells must be pluripotentized to keep the body from rejecting them and to try and make it so that they will replicate the types of cells that you want them to replicate.Also, identifying and harvesting the cells is difficult, costly and often painful for the donor.There is also umbilical cord stem cells but they have to be harvested while the umbilical cord is still alive so it is very hard to find donors for that.Unused IVF blastocysts are still the most widely desired and used source for stem cells.
Micki - 11-May-14 @ 8:20 PM
Is there a ethically clear way to get stem cells? I understand that embroynic stem cells are the only way currently but is anyone trying to make artificial stem cells so that it wouldnt disturb anyone's morals?
JDC - 24-Apr-14 @ 6:57 PM
To the point explanation. Thank you for incorporating all the articles about stem cells, really helped.
sasha - 28-Mar-14 @ 11:37 AM
Iam a biochemist and adermatologist interested in stem cell research ihad two papers about human origin and induced pluripotent stem cells . I would to participate in such research if I find the chance. Khanks a lot .
Elsheihk - 16-Jul-13 @ 1:14 AM
Induced pluripotent stem cells would seem to get round the ethical issue as they are adult somatic cells that have been effectively reprogrammed to act like embryonic stem cells in that they can be developed into any cell or tissue in the body. It seems like something out of science fiction to grow your own tissues and organs and just replace the aging or diseased parts much like you might do on a car. I still think they have a long way to go in actually working out how to develop the stem cells into specialized cells and also how to transplant the organs successfully. Although given that the stem cells will have come from the individual receiving the transplant there is less chance of rejection but still could they one day transplant a brain ?
http://beyouthful.ne - 6-May-13 @ 5:14 AM
Thanks! This was very helpful for my genetics project in science!
NOTPABLO - 2-May-13 @ 6:23 PM
I need a 2 to 4 lines about pluripotent stem cells except defination
raj - 30-Dec-12 @ 4:51 PM
I amconfused; I are reviewing records for a deceased patient who had a peripheral stem cell transplant from an unrelated donor, later relapsed and had MESENCHYMAL stem cell treatment.What type cells are used in a first time allogeniec stem cell transplant? Multipotent?The patient had relapse and was refractory to multiple treatments before the mesenchymal treatment. Ultimately, it also failed him.I am trying to understand his disease process.He was AML, M-2, preceded by MDS.A young man, too, only 49. I am a legal nurse consultant and transplant medicine interests me, though I don't understand a lot of it yet.
Jan - 25-Nov-12 @ 11:57 PM
can stem cels cure infertility?
benjie - 7-Sep-12 @ 10:01 PM
I've wrestled with the ethical questions on embryonic stem cells.I also have been diagnosed with Parkinson;s Disease since 2005.The speed in which this disease is overtaking my 53 year old body is terrifying.Any new breakthroughs that could possibly help defeat this and other Chronic Diseases, please,Please,PLEASE hurry.I for one will not last much longer.I will debate any ethical concerns you might have as soon I'm well.
djvc - 29-Dec-11 @ 3:26 AM
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