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Ovarian Function and Stem Cells

By: Ian Murnaghan BSc (hons), MSc - Updated: 17 Sep 2019 | comments*Discuss
 
Stem Cells Ovarian Functioning Premature

Ovarian function in women prior to menopause is an important topic. That’s because a number of women who are under the age of forty will develop premature ovarian failure. Statistics estimate that one percent will experience this condition.

What is Premature Ovarian Failure?

When the ovaries of a woman younger than the age of forty stop working, this is known as premature ovarian failure. When this happens, a woman will no longer produce eggs or hormones from her ovaries.

One of the biggest issues when this occurs is that a woman will no longer be fertile. At present, we have no treatment to reverse this process and restore a woman’s fertility. With many women delaying family planning until their thirties or forties, the effects can be particularly devastating for women who experience premature ovarian failure.

Searching for New Treatments

In one recent study, however, researchers were able to restore the ovarian function in rats that had premature ovarian failure. Although it is still a very early study and certainly requires long-term testing on humans, it brings some hope that we may one day find a way to treat this problem.

Stem Cells to Restore Ovarian Function

By using embryonic rat stem cells, researchers found they were able to bring back ovarian functioning in the rats. Initially, they studied sixty mature female rats by dividing them into four groups.

Testing Stem Cells on Ovarian Functioning

In the first group of rats, no treatment was received. This means that the first group of rats was considered the control group to compare other groups to in the experiment. All the other rats in groups two to four received a chemical to trigger ovarian failure. These groups had fifteen rats per group.

For the second group, once ovarian failure had occurred, they were treated via injections of the stem cells. By using male stem cells, researchers could then see exactly where the stem cells were located once injected. They would look for a Y chromosome to identify this location.

For the third group of rats that had ovarian failure, they received a saline solution while the fourth group with ovarian failure received nothing. Researchers then assessed levels of two important hormones to see if the rats that received a treatment went back to normal.

Restored Ovarian Functioning

Results were very positive, showing that within a two week time period, the rats that received the stem cell treatment had fully functioning ovaries again. By eight weeks later, the hormone levels of these rats were the same as the rats who never had ovarian failure – the first group.

Helping Women Regain Fertility

An important step now is to actually investigate how the rats will reproduce and to then ensure that the offspring of the rats are healthy. The study is only a proof-of-concept one and we are still many years away from a treatment. The research does, however, offer real hope that one day in the future we may be able to restore ovarian function in the many women who suffer from premature ovarian failure.

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Hi I am 30 years old. Have recently been diagnosed with Early menopause. With 1 year amenorrhea profile. I have done alot of research into stem cell therapy and am very interested and willing to travel. I currently reside in Wiltshire. X2 blood test results are as follows: 01/03/19 Serum LH level 40.2 iu/L Serum follicle stimulating hormone level 65.6 iu/L Serum prolactin level 295 mu/L [50.0 - 500.0] Serum testosterone level 2.6 nmol/L [0.5 - 2.6] 16/04/19 Gonadotrophin level  Serum LH level 57.8 iu/L Serum follicle stimulating hormone level 104.5 iu/L Serum prolactin level 275 mu/L [50.0 - 500.0] Serum testosterone level 1.5 nmol/L [0.5 - 2.6]
Natalie 89 - 17-Sep-19 @ 2:16 PM
Hi, i would like to be considered for this trial... i have been been toldi have premature ovarian failure
R - 13-Aug-19 @ 1:48 PM
I'm 39 and I don't have kids i've been diagnosedwith prematureovarianfailure I'd like to try this new treatment.
Hass - 15-Jun-19 @ 9:38 PM
I would also be interested in the trial please.
Deedee - 4-Jun-19 @ 4:25 AM
Hi there, I have been diagnosed with Poor Egg Reserve.But I really want a baby.A doctor suggested that I undergo stem cell therapy.They will take the stem cells from my blood and inject it in my ovaries and in 2-3 months they will take any follicles that may grow and fertilise it and implant it as an embryo. I wish to know whether it is feasible and worth a procedure and whether there are any risk
Aneer - 31-May-19 @ 8:22 AM
I'm 34 and was told have premature ovary failure
Kadii - 29-May-19 @ 11:07 PM
Hello, I am interested in this trial also. Could you please contact me with any info thank you
Deedee - 27-May-19 @ 1:06 AM
I'm very interested in this treatment I went though early menopause at the age of 24 and I'm now 33 with 3 failed ivf attempts if anything like this comes to the UK dont hesitate to contact me
Emz - 1-May-19 @ 8:53 AM
I'm 33 and desperate to have my own child, my partner has children so we will have to pay for egg donation and we are struggling to raise the money. If any trials or options are available please can we have some information?
Iris - 31-Mar-19 @ 11:29 PM
I am 42 years old, I live in London. I would love to take part in stem cell research. Please consider me in your next clinical trial. Regards Sania
Sonia - 28-Mar-19 @ 9:41 AM
I would like to be included in study of ovarian MU stem cells.I'm 53 yrs old
Cindy - 22-Mar-19 @ 8:33 AM
I am 51 years old, I would love to take part in stem cell research. Please consider me in your next clinical trial. Thank you
Kas - 16-Mar-19 @ 9:34 PM
Hello Can I be considered for your trial please I am 43 year old been trying for over 5 years. 3 failed IVF due to non fertilization and very low AMH. Thank you
Dimi Bostock - 2-Mar-19 @ 12:17 AM
Hello , I am 32 years .can I have a free trial I had cancer 14 yearsback.now my ovarian reserves are less and I cant afford any treatment privately .can I have this trial plz I dont have any kids
Noni - 17-Feb-19 @ 6:53 AM
Can I be included in you trial. I am 51 and I want another child. I had a child naturally 5 years ago
Tina - 16-Jan-19 @ 11:26 PM
I am 46 years old and have three failed cycles of IVF and have been told that donor eggs would be the best option for me, but I would love a child that is genetically my own.Please consider me for any trial you may be running, travelling would not be a problem for us. Neither of us has any children and to try this would be our first baby.
Ellen - 13-Jan-19 @ 4:18 PM
I am 47 year old. 1st IVF with my own egg failed. Please add me on your trial. Thank you.
Ella - 9-Jan-19 @ 3:54 PM
Premature ovarian failure at 37. Very low amh. Nil family history. Desperate to have my 1st child. 3 ivf failed over 2 years. Add me to your list as interested party !Sonya
Sunjuice - 7-Dec-18 @ 8:16 AM
Hello, I am 54 and post menopausal for 2 years , I am intersted in participating in stem cell theraphy, thank you.
madenci - 4-Dec-18 @ 6:19 AM
I am 50, single and have no kids previously, Desperate for having baby. I have no problem to travel for this trial. please consider me. thank you
Asma Khan - 28-Nov-18 @ 3:15 PM
I am 44, with POF since teenager. my FSH could reach 150. my AMH is less than 0.1. Desperate for having baby. I have no problem to travel for this trial. please consider me. thank you
Lina - 1-Nov-18 @ 2:24 PM
I am 46 years old. I have POF when I was 21. Doctors diagnosed it later. I have osteoporosis and osteoarthritis. I want to get healed and become healthy. I suffered many fractures. I am a strong woman in my heart. I would love to volunteer for trials
GA - 30-Sep-18 @ 7:59 PM
Hello. I am 43 years old,and I am on the menopause from 8 years now. I really want to be part of your trial. Please give me a chance to have a child. Thank you.
Elena - 26-Sep-18 @ 3:50 PM
I am a 49 year old Asian woman with no children.I was diagnosed with POF 13 years ago.I am an American citizen and able to travel for this trial.Please consider me in your next clinical trial.
Lilly - 17-Sep-18 @ 11:57 PM
Hello.I am 38 years of age and been diagnosed with POF.I started an ivf cycle which was cancelled due to poor response to medication. I have never been pregnant before and would be really interested to take part in any studies/trials available or any information available to pursue treatment Thanks Kat
Kat - 17-Sep-18 @ 6:28 PM
I would like to participate in any stem cell trial to achieve pregnancy, I am almost 47 years old with one child 4 years old and would like another one. Is there any place in London you could do it? A piece of advise would be very much appreciated.
Anna - 30-Jul-18 @ 10:25 AM
When I was 16 years old I went on an extreme diet and developed an eating disorder. I was 110 pounds and 5’6” until I got help when I was 27. I gained weight quickly and maintained a weight of 136 pounds with a healthy lifestyle. I’m now 30 years old with ostopoenia. My menses never returned. I do not have withdrawal bleeds when using medroxyprogesterone, nor does birth control help in regulating menses. I have had MRIs and ultrasounds confirming that I have Hypothalamic Amenorrhea. I would love to be a part of a stem cell research group to see if treatment like this could help people in my situation.
Ash - 29-Jul-18 @ 6:06 PM
Im 45 never been pregnant my husbsnd snd I have been trying for 6 years with no luck.Please consider me for the trail. Thank you??
Jen - 26-Jul-18 @ 4:03 PM
I am 35 and been trying to conceive for about 6-7 years. In my life I never even fell pregnant. To investigate I don'e all if the test and they were normal, however I have endometriosis and it is this disease that I believe doesn't want me to fall pregnant. Please consider me for the trial
Agnes - 25-Jul-18 @ 12:21 PM
Hi, I’m 27 years old, I was diagnosed with POF 8 years ago. I want to have a child. If you can include me in your trials And I’m ready to be a candidate if it’s possible. Thanks
Susu - 23-Jul-18 @ 2:58 PM
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