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Totipotent Stem Cells

By: Ian Murnaghan BSc (hons), MSc - Updated: 18 Jul 2019 | comments*Discuss
Totipotent Pluripotent Stem Cells

You may already be familiar with the basics of stem cells but perhaps you weren't aware that there are different types, or potencies of stem cells.

Totipotent stem cells are one of the most important stem cells types because they have the potential to develop into any cell found in the human body. In human development, the egg cell in a woman and the sperm cell from a man fuse together to form a single cell called the zygote. The zygote divides numerous times and forms cells that are the precursors to the trillions of cells that will eventually constitute the human body.

It may sound rather complex and in a sense it is, when you consider that a simple cell has the potential to develop into a specialised one with a specific job in the body. It is simple, however, in that it's a clear sequence of events that begins with an egg cell and a sperm cell. The zygote from that fusion of an egg cell and a sperm cell then begins cell divisions that are capable of forming the entire human body. It is these cells that are totipotent, so called because their potential is 'total.'

What Happens to the Zygote?

Totipotent stem cells are perhaps the most versatile of the stem cell types. As explained, a totipotent zygote cell is created when a single celled sperm and egg unite. This totipotent fertilised egg has the potential to give rise to virtually all human cells, such as nerve or heart. It is during the early cell divisions in embryonic development that more totipotent cells are produced. Within several days, these totipotent cells divide and create replicas, therefore producing more totipotent cells. It is after approximately four days that the cells begin to specialise into pluripotent cells, which can go on to specialise further but can't ever produce an entire organism as totipotent cells can. Basically, the pluripotent stem cell can do everything the totipotent one can except for creating an entire organism.

When Does a Totipotent Stem Cell Change?

A fertilised egg has totipotency, or total potential for about four days. Days after fertilisation, however, the totipotent stem cell divides and then matures to cause more specialised stem cells called pluripotent stem cells. Like totipotent stem cells, pluripotent stem cells can self-renew and give rise to trillions of cells in the body.

What are the Special Qualities of a Totipotent Stem Cell?

The earlier stage foetal stem cells are totipotent because:
  • They have the ability to become any cell type in a fully developed human
  • They have the ability to replicate in unlimited numbers without losing their total potency
The ability of totipotent stem cells to differentiate into any cell in an organism including embryonic tissue is an important distinguishing quality. A human totipotent stem cell can thus develop into any cell in the body, including placental cells.

Benefits of Totipotent Stem Cells

All stem cells have the potential to develop into different cell types, but totipotent cells can develop into any cell type, which makes them ideal for cell and gene therapies as well as tissue engineering for transplants and replacement of diseased cells. This means that the therapeutic value of totipotent stem cells is enormous. By learning about the process of division, we can find out what goes wrong in disease states and then investigate ways to prevent diseased cell production and division.

A formidable challenge is for researchers to appease the ethical concerns around the harvesting of totipotent foetal cells. This is balanced by supporters who cite the huge range of benefits to those suffering from disease. For now, there doesn't appear to be an answer to satisfy all members of the public as well as scientists and government agencies. The promise of effective treatments or even a cure for many debilitating diseases is, however, reason enough to search for treatments with totipotent stem cells that everyone can live with.

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What drives totipotent stem cells differentiation. I wonder if anybody knows the answer? It couldn't be in the DNA must be an external force?
eric - 18-Jul-19 @ 2:03 AM
the data uploaded this site can help any biology thinkers to grow a enormous knowledge cloud.I am very thankfull
SUBHO - 14-Jun-18 @ 3:31 AM
Stem cells are a hoax developed by the government to distract you from the violent acts undergoing in 3rd world communities
Ram - 1-May-18 @ 9:47 AM
Is pulipotent cell a cell of the blastula
NAPOLEON - 15-Nov-17 @ 3:31 AM
OK its fine. Can we make totipotent cells for me by means of gene cloning? If possible how?
Diwa - 2-Aug-17 @ 9:58 PM
Totipotency of stem cells are playing an important role in life.What if a person who has no hand or any part of limbs can it be generated through the totipotency of the stem cells to give a new limb or any part or organ to sustain anybodies life & can it be done when we collect those stem cells from the fertilised zygot of a particular person when that person losses a part to connect it without any rejection could be possibe i hope
Goku - 14-Apr-17 @ 5:53 PM
withtotipotent cell, so many diseaseconditioncanbesolved, takeforinstance, cancer and geneticabnormalsuch as heamoglobinopath(scdx )
Baba - 23-Oct-16 @ 1:46 PM
Wikipedia (and a few other sources) say that "totipotent" cells are sometimes called "omnipotent" cells. This sounds crazy to me ... What has theology to do with biology (or cytology)? Can someone clarify this issue: In biology (cytology), are "totipotent" and "omnipotent" synonymous terms?
MicroTech - 5-Aug-16 @ 9:25 AM
Is it possible to produce a entire human from totipotent stem cell without involvement of sex cells...
Deepak Kishan - 14-Apr-16 @ 8:01 PM
Is it possible to store totipotent cells and create an entire human after so many years because we can produce twins at early blastula stage so can we make twins at different times.
praveen - 11-Nov-15 @ 9:05 PM
Trying to understand the stages of a cell from toniponet to unipontent
Raja - 1-Nov-15 @ 5:33 PM
Very useful for this essay I don't want to compose.
Dr-Willakers - 1-Mar-15 @ 6:22 PM
interesting. and helpful for this essay i dont want to write.
informed human - 1-Mar-15 @ 6:20 PM
Now this information is really great, but would you mind telling me why we are not using totipotent stem cells very much anymore?
Meg - 16-Oct-14 @ 2:43 AM
can these totipotent stem cells be stimulated to recreate themselves? of course it couldn't be done to extremes but by doing that couldn't you further it by using it as a stockpile of sorts to treat diseases, and with further study couldn't this help treat or even cure cancer? and if something can stop cancer, which is simply incorrectly reproduced cells, couldn't that prevent a body from deteriorating, which means we could greatly increase lifespans?
dante - 22-May-14 @ 4:42 AM
So what are the types of cells that totipotent cells can differentiate but pluripotent cells cannot? What is the difference between the unipotent stem cells and normal cells? Unipotent cells ca give rise to only one cell type but normal cells can also give rise to only one cell type by meiosis or mitosis. Why embryonic stem cells face high possibility of transplant rejection?
urghhhh - 5-Oct-13 @ 10:46 AM
where are totipotent cells presented in humans
guddu - 26-Aug-12 @ 7:57 AM
Thank you for this. Simple and very well explained - it helped me a lot understanding the basics of the different types of stem cells.
sunny - 7-Feb-12 @ 5:07 PM
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